Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 Mar 16:S2451-9022(26)00078-9. doi: 10.1016/j.bpsc.2026.03.005. Online ahead of print. ABSTRACT BACKGROUND: The brain age biomarker estimates biological age from brain structure and is discussed as a potential screening tool for clinically relevant brain aging patterns in individuals. For brain age estimates to be of clinical utility, they must be meaningful for individual patients and free from systematic bias. Here, we investigate how biases from training data age-skewness, which we call distribution bias, impact the reliability and biological interpretability of this promising biomarker. METHODS: Using Monte Carlo simulations with data from 9,305 individuals and […]
Monat: März 2026
Marburg joins the Bernstein Network
The University of Marburg has become a new node of the Bernstein Network for Computational Neuroscience. More information can be found here.