Behav Res Methods. 2026 Aug 24;58(10):279. doi: 10.3758/s13428-026-03150-6. ABSTRACT Tetris is a widely used computer game, not only for entertainment purposes but increasingly in cognitive and clinical neuroscience research. Despite its frequent application in experiments, the neural mechanisms underlying gameplay remain insufficiently understood. Prior work suggests that cognitive control during complex visuospatial tasks, like Tetris, engages the attention network as well as regions supporting visuospatial working memory, mental imagery, and motor planning. However, researchers currently lack a standardized paradigm to investigate these processes. To address this gap, we introduce Tetrix, a novel and flexible Tetris-based paradigm designed for […]
Monat: August 2026
Negative expectations in major depression: Association with brain structure and course of illness
J Affect Disord. 2026 Aug 21:122410. doi: 10.1016/j.jad.2026.122410. Online ahead of print. ABSTRACT BACKGROUND: Negative expectations towards the future are frequently observed in patients with major depressive disorder (MDD) and linked to less favourable outcomes like worse treatment response and suicidal behaviours. Despite clinical significance, the neurobiological underpinnings of negative expectations remain largely unexplored. METHODS: This study compared structural MRI morphometric gray matter volume (SPM/CAT12) and two-year longitudinal clinical data between two groups of patients with DSM-IV-TR MDD (total N = 330), matched for age, sex, severity of depressive symptoms (HAMD), and global functioning (GAF scale), but differing […]