J Affect Disord. 2026 Apr 9:121779. doi: 10.1016/j.jad.2026.121779. Online ahead of print. ABSTRACT Formal thought disorder (FTD), involving disruptions in language and thought, is commonly linked to schizophrenia but is also prevalent and debilitating in Major Depressive Disorder (MDD). Despite its clinical relevance, few studies have comprehensively examined FTD in MDD using operationalized rating scales and MR neuroimaging. FTD was assessed in 379 acute MDD patients using the Scale for the Assessment of Positive and Negative Symptoms. Whole-brain MRI was used to examine associations between FTD severity and gray and white matter structures, as well as resting-state functional […]
